Ecopharmacovigilance: Concepts, Developments, and Implementation in Reducing the Environmental Impact of Phamaceuticals

Fauziah Hasdin; Sri Magfirah  HS

doi:10.55927/eajmr.v5i8.253

Authors

Fauziah Hasdin Universitas Negeri Makassar
Sri Magfirah HS Universitas Negeri Makassar

DOI:

https://doi.org/10.55927/eajmr.v5i8.253

Keywords:

Ecopharmavigilance, Environmental risk assessment, Phamaceutical residues, Green pharmacy, Environmental pollution

Abstract

The increasing use of pharmaceuticals has led to greater release of pharmaceutical residues into the environment, posing risks to aquatic organisms, promoting bioaccumulation, and contributing to antimicrobial resistance. This study reviewed the development, implementation, and challenges of ecopharmacovigilance (EPV) through a narrative review of 30 articles published between January 2021 and June 2026. The findings indicate that pharmaceutical residues originate from human and veterinary excretion, healthcare facility effluents, pharmaceutical manufacturing, and improper disposal of unused medicines. These residues contribute to environmental contamination, ecosystem disruption, and the emergence of antimicrobial resistance. The implementation of EPV is supported by Environmental Risk Assessment (ERA), environmental monitoring technologies, the One Health approach, and green pharmacy strategies. However, inadequate monitoring systems, fragmented regulatory frameworks remain.

References

Arumugam, A., Lee, K. E., Ng, P. Y., Shamsuddin, A. S., Zulkifli, A., & Goh, T. L. (2026). Pharmaceuticals in Water: Fate, Health Risks, Treatment and Governance for Sustainable Management. Water, Air, & Soil Pollution 2026 237:14, 237(14), 828-. https://doi.org/10.1007/S11270-026-09479-0

Baaloudj, O., Scrano, L., Bufo, S. A., Modley, L. A. S., Lelario, F., Zizzamia, A. R., Emanuele, L., & Brienza, M. (2025). Environmental Fate, Ecotoxicity, and Remediation of Heterocyclic Pharmaceuticals as Emerging Contaminants: A Review of Long-Term Risks and Impacts. Organics 2025, Vol. 6, Page 1, 6(1), 1. https://doi.org/10.3390/ORG6010001

Belle, G., Moodley, B., Moodley, R., Omotola, E. O., Truter, C., Olatunji, O., & Oberholster, P. (2025). Occurrence and detection of selected pharmaceuticals of emerging concern: potential risks for aquatic ecosystems and human health. Discover Applied Sciences 2025 7:10, 7(10), 1078-. https://doi.org/10.1007/S42452-025-07716-5

Caban, M., & Stepnowski, P. (2021). How to decrease pharmaceuticals in the environment? A review. Environmental Chemistry Letters, 19(4), 3115–3138. https://doi.org/10.1007/S10311-021-01194-Y

Cannata, C., Backhaus, T., Bramke, I., Caraman, M., Lombardo, A., Whomsley, R., Moermond, C. T. A., & Ragas, A. M. J. (2024). Prioritisation of data-poor pharmaceuticals for empirical testing and environmental risk assessment. Environment International, 183. https://doi.org/10.1016/j.envint.2023.108379

Cristini, I., Poluzzi, E., Soardo, F., Crisafulli, S., Polesello, S., Kirchmayer, U., Milani, M., Russo, F., Nicoletti, M., Scroccaro, G., Deambrosis, P., Tavakolian Haghighi, S., Grisotto, J., Moretti, U., Paolone, G., & Trifirò, G. (2025). A narrative review on the environmental impact of medicines: from water analysis and in vivo studies to prescribing appropriateness, based on European and Italian legal frameworks. Frontiers in Drug Safety and Regulation, 5, 1681648. https://doi.org/10.3389/FDSFR.2025.1681648/TEXT

Dikshit, H. (2024). Ecopharmacovigilance: A new direction toward “One Health.” Journal of Indira Gandhi Institute of Medical Sciences, 10(1), 17–23. https://doi.org/10.4103/JIGIMS.JIGIMS_57_23

Ferrari, R. (2015). Writing narrative style literature reviews. Medical Writing, 24(4), 230–235. https://doi.org/10.1179/2047480615Z.000000000329

García, M., Cherian, J. J., & Lertxundi, U. (2024). Incorporating the One Health Philosophy into pharmacovigilance: Ecopharmacovigilance. British Journal of Clinical Pharmacology, 90(11), 2953–2954. https://doi.org/10.1111/BCP.16254

Gómez-Oliván, L. M. (2026). Eco-Pharmacovigilance at the Water–Health Interface: Mechanistic Ecotoxicology for One Health in the Age of Mixtures. TecnoLógicas, 29(65), e3982–e3982. https://doi.org/10.22430/22565337.3982

Greenhalgh, T., Thorne, S., & Malterud, K. (2018). Time to challenge the spurious hierarchy of systematic over narrative reviews? European Journal of Clinical Investigation, 48(6). https://doi.org/10.1111/ECI.12931

Gurudiwan, P., & Mire, S. K. (2024). A Review of Pharmaceuticals in Aquatic Environments Risk Assessment and Ecological Impacts. Natural and Engineering Sciences, 9(3), 88–99. https://doi.org/10.28978/NESCIENCES.1606589

Helwig, K., Niemi, L., Stenuick, J. Y., Alejandre, J. C., Pfleger, S., Roberts, J., Harrower, J., Nafo, I., & Pahl, O. (2024). Broadening the Perspective on Reducing Pharmaceutical Residues in the Environment. Environmental Toxicology and Chemistry, 43(3), 653–663. https://doi.org/10.1002/ETC.5563

Inaudi, P., Abollino, O., Bottoni, P., Grifa, R. A., & Caroli, S. (2025). The role of spectrochemical techniques for the detection, identification, and quantification of residues and metabolites of pharmaceuticals in the environment: a review of developments in ecopharmacovigilance over the past decade. Applied Spectroscopy Reviews, 60(9–10), 1066–1135. https://doi.org/10.1080/05704928.2025.2507212

Khamkar, P., Mahapatra, D. K., & Kadam, A. (2021a). Ecopharmacovigilance: Perspectives, concepts, applications, and relationships in modern context. Journal of Pharmacovigilance and Drug Research, 2(1), 9–15. https://doi.org/10.53411/JPADR.2021.2.1.2

Khamkar, P., Mahapatra, D. K., & Kadam, A. (2021b). Ecopharmacovigilance: Perspectives, concepts, applications, and relationships in modern context. Journal of Pharmacovigilance and Drug Research, 2(1), 9–15. https://doi.org/10.53411/JPADR.2021.2.1.2

Maculewicz, J., Kowalska, D., Świacka, K., Toński, M., Stepnowski, P., Białk-Bielińska, A., & Dołżonek, J. (2022). Transformation products of pharmaceuticals in the environment: Their fate, (eco)toxicity and bioaccumulation potential. Science of the Total Environment, 802. https://doi.org/10.1016/j.scitotenv.2021.149916

Madikizela, L. M., & Netshithothole, R. (2026). Non-steroidal anti-inflammatory drugs, analgesics, and their metabolites in the coastal environment: the escape to seawater and concerns. Environmental Science: Advances, 5(4), 927–940. https://doi.org/10.1039/D5VA00428D

Nana Shashiashvili, N. S. (2025). The Role of Pharmacoepidemiology in Economic Models and Databases. Economics, 107(1–2), 36–40. https://doi.org/10.36962/ECS107/1-2/2025-36

Obando, M. C. V., Pardillo, T. B., Velázquez, M. del R. H., & Díaz, M. F. (2026). Impacto ambiental de productos dermatológicos: Una revisión sistemática sobre ecofarmacovigilancia. ASCE MAGAZINE, 5(1), 1557–1579. https://doi.org/10.70577/ASCE.V5I1.656

Oldenkamp, R., Hamers, T., Wilkinson, J., Slootweg, J., & Posthuma, L. (2024). Regulatory Risk Assessment of Pharmaceuticals in the Environment: Current Practice and Future Priorities. Environmental Toxicology and Chemistry, 43(3), 611–622. https://doi.org/10.1002/ETC.5535

Page, M. J., Mckenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., Mcdonald, S., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. https://doi.org/10.1136/bmj.n71

Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., Mcdonald, S., … Mckenzie, J. E. (2021). PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ, 372. https://doi.org/10.1136/BMJ.N160

Punginelli, D., Maccotta, A., & Savoca, D. (2024). Biological and Environmental Impact of Pharmaceuticals on Marine Fishes: A Review. Journal of Marine Science and Engineering 2024, Vol. 12, Page 1133, 12(7), 1133. https://doi.org/10.3390/JMSE12071133

Roveri, V., Correia, A. T., dos Santos, P. G., Ferreira Povoas, M. N., Toma, W., Seabra Pereira, C. D., & Guimarães, L. L. (2026). AI-assisted QSAR framework for ecological risk assessment of pharmaceuticals: integrating experimental, mechanistic, and deep learning evidence. Computational Toxicology, 37. https://doi.org/10.1016/J.COMTOX.2026.100403

Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/J.JBUSRES.2019.07.039

Spilsbury, F. D., Inostroza, P. A., Svedberg, P., Cannata, C., Ragas, A. M. J., & Backhaus, T. (2024). Defining the data gap: What do we know about environmental exposure, hazards and risks of pharmaceuticals in the European aquatic environment? Water Research, 251. https://doi.org/10.1016/j.watres.2023.121002

Uluseker, C., Lofts, S., & Harrison, S. (2025). Advances and challenges in modelling the environmental fate and exposure of pharmaceuticals: a comprehensive review. Environmental Science. Processes & Impacts, 27(12), 3700–3724. https://doi.org/10.1039/D5EM00449G

Vitanza, A. M., Oliveri Conti, G., & Ferrante, M. (2025). Environmental sustainability of healthcare system in the era of One Health: a pharmaceuticals residues point of view. One Health Advances, 3(1). https://doi.org/10.1186/S44280-025-00103-0

Welch, S. A., Moe, S. J., Sharikabad, M. N., Tollefsen, K. E., Olsen, K., & Grung, M. (2023). Predicting Environmental Risks of Pharmaceuticals from Wholesale Data: An Example from Norway. Environmental Toxicology and Chemistry, 42(10), 2253–2270. https://doi.org/10.1002/ETC.5702

Zampelli, S., & Verna, R. (2025a). Environmental Pollution from Pharmaceuticals. Life, 15(9), 1341. https://doi.org/10.3390/LIFE15091341

Zampelli, S., & Verna, R. (2025b). Environmental Pollution from Pharmaceuticals. Life 2025, Vol. 15, Page 1341, 15(9), 1341. https://doi.org/10.3390/LIFE15091341

Zhang, D., Liu, J., Jiang, X., Cao, K., Yin, P., & Zhang, X. (2016). Distribution, sources and ecological risk assessment of PAHs in surface sediments from the Luan River Estuary, China. Marine Pollution Bulletin, 102(1), 223–229. https://doi.org/10.1016/j.marpolbul.2015.10.043